Search results for " Subependymal"

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Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects

2016

Relatively quiescent somatic stem cells support life-long cell renewal in most adult tissues. Neural stem cells in the adult mammalian brain are restricted to two specific neurogenic niches: the subgranular zone of the dentate gyrus in the hippocampus and the ventricular-subventricular zone (V-SVZ; also called subependymal zone or SEZ) in the walls of the lateral ventricles. The development of in vivo gene transfer strategies for adult stem cell populations (i.e. those of the mammalian brain) resulting in long-term expression of desired transgenes in the stem cells and their derived progeny is a crucial tool in current biomedical and biotechnological research. Here, a direct in vivo method …

0301 basic medicineEpendymal CellNeurogenesisGeneral Chemical EngineeringGenetic VectorsStem cellsBiologyTransfectionGeneral Biochemistry Genetics and Molecular BiologySubgranular zoneMice03 medical and health sciencesSubependymal zoneNeural Stem CellsEpendymal cellEpendymaLateral VentriclesDevelopmental biologyNichemedicineSubependymal zoneAnimalsNeurogeneticsGeneral Immunology and MicrobiologyLateral ventricleGeneral NeuroscienceLentivirusNeurogenesisGene Transfer TechniquesBrainNeural stem cellCell biology030104 developmental biologymedicine.anatomical_structureVentricular-subventricular zonenervous systemNeural stem cellIssue 108NeurogenèticaStem cellCèl·lules mareDevelopmental biology; Ependymal cell; Issue 108; Lateral ventricle; Lentivirus; Neural stem cell; Neurogenesis; Niche; Subependymal zone; Ventricular-subventricular zone; Animals; Brain; Ependyma; Lateral Ventricles; Lentivirus; Mice; Neural Stem Cells; Transfection; Gene Transfer Techniques; Genetic VectorsDevelopmental biologyNeuroscienceAdult stem cellJournal of Visualized Experiments
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Morphological Changes within the Rat Lateral Ventricle after the Administration of Proteasome Inhibitors.

2015

The broad variety of substances that inhibit the action of the ubiquitin-proteasome system (UPS)—known as proteasome inhibitors—have been used extensively in previous studies, and they are currently frequently proposed as a novel form of cancer treatment and as a protective factor in intracerebral hemorrhage treatment. The experimental data on the safest route of proteasome inhibitor administration, their associated side effects, and the possible ways of minimizing these effects have recently become a very important topic. The aim of our present study was to determine the effects of administering of MG-132, lactacystin and epoxomicin, compounds belonging to three different classes of protea…

MalePathologymedicine.medical_specialtyProteasome Endopeptidase ComplexEpendymal CellRosette FormationLactacystinlcsh:MedicineBiologyGlial scarchemistry.chemical_compoundLateral ventriclesEpoxomicinEpendymaLateral VentriclesmedicineAnimalsRats Wistarlcsh:ScienceMultidisciplinaryUbiquitinlcsh:RRatsmedicine.anatomical_structureProteasomechemistryGlioma SubependymalProteasome inhibitorlcsh:QAtrophyEpendymaProteasome Inhibitorsmedicine.drugResearch ArticlePloS one
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